Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone

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Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone.

RATIONALE Acute doses of buprenorphine can precipitate withdrawal in opioid dependent persons. The likelihood of this withdrawal increases as a function of the level of physical dependence. OBJECTIVES To test the acute effects of sublingual buprenorphine/naloxone tablets in volunteers with a higher level of physical dependence. The goal was to identify a dose that would precipitate withdrawal...

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Electrocardiogram characteristics of methadone and buprenorphine maintained subjects.

There has been recent concern about the association between high dose methadone and prolongation of QTc in the electrocardiogram. QTc is the time from the beginning of the QRS complex to the end of the T have as measured on an electrocardiogram and corrected for heart rate. To date, no association has been made between methadone and buprenorphine in commonly used doses and prolonged QTc. Electr...

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COMPARISON OF ACUTE AND CHRONIC EFFECTS OF NIFEDIPINE ON NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN MICE

Mice were rendered tolerant and dependent to morphine by subcutaneous injection of morphine over a period of 5 days. The effects of acute and chronic administration of dihydropyridine calcium channel antagonist nifedipine on the development of tolerance and naloxone-precipitated morphine withdrawal signs were investigated. A single injection of nifedipine proved to be effective in inhibiti...

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Suppressive Effects of Rosa Damascena Essential Oil on Naloxone-Precipitated Morphine Withdrawal Signs in Male Mice

This research was done to test the effect of Rosa damascena essential oil on withdrawal signsof naloxone-precipitated morphine in male mice. Morphine dependence was induced by injection(IP) three times daily at doses of 50, 50 and 75 mg/kg, respectively, for 3 days. On day 4,after the last administration of morphine, Rosa damascena essential oil was administered atdifferent concentrations (5, 2...

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The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patients.

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ژورنال

عنوان ژورنال: Drug and Alcohol Dependence

سال: 2007

ISSN: 0376-8716

DOI: 10.1016/j.drugalcdep.2007.04.006